Special Mouse Stocks-congenic and recombinant inbred strains 4.įoundation Stocks-pedigreed source colonies for inbred strains 5. Induced Mutants-these include transgenics, induced and targeted mutations 2. Internally, TJL has divided its 1,800 or so strains of mice into seven categories, each managed in a separate subunit known as a resource (instead of a department or division): 1. At this point they become Jackson Laboratory (JAX) mice and are distributed as such according to TJL policies. Mice that are accepted by TJL must all be cesarean rederived to ensure that they are disease free. The laboratory also maintains pedigreed stocks of mouse strains using breeding programs that are designed to ensure their genetically unique qualities. These mice from external sources may be spontaneous mutations, or they may be induced mutations. TJL develops mutant strains of mice as well as accepting mice from scientists who wish to make them available to other scientists. Production, Sale, Derivation, and Maintenance of Mice The total operating budget for TJL for 1995 was approximately $45 million, and about half of that is related to maintaining and distributing animal resources (mice) and related services, that is, production and sale of specific mouse mutants, maintenance of selected breeding stocks, derivation of selected strains or congenic production, surgical manipulations, embryo conservation, and bioinformatics. Support for the laboratory's activities comes from a combination of federal agencies (National Institutes of Health and National Science Foundation ), other health organizations (Howard Hughes Medical Institute, American Cancer Society, American Health Association, Cystic Fibrosis Society, Multiple Sclerosis Society, March of Dimes, and others), and fees from services or sales of laboratory mice. TJL is governed by a Board of Trustees that includes both scientists and nonscientists a Board of Scientific Overseers and a Director, who is also provided advice in different areas by staff scientists on four standing committees. Providing the essential genetic resources for other scientists to do that research throughout the world and 3.Įducating the next generation of scientists to carry out this work.
Providing new information to the scientific community through basic genetic research using mice 2. The laboratory describes its mission as 1.
TJL is internationally recognized as the preeminent source of laboratory mice.
For more than 60 years, The Jackson Laboratory (TJL), a private, nonprofit, research institution on Mount Desert Island off the coast of Maine, has been the major repository for genetically defined mice.
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